This website was originally set up in 1999, whilst I was still riding as a jump jockey for the champion racehorse trainer Martin Pipe. I retired from riding in 2002 and much of the original racing content of the site can be accessed using the links at the top of the page. After retiring from race riding I worked in a number of managerial jobs and in 2007 I decided to do a degree to further my knowledge and strengthen my CV.
I obtained a first class honours degree in Equine Management from the Royal Agricultural College and I have provided further information on my undergraduate work here. I greatly enjoyed my time studying for my undergrad degree, and I found studying genetics really fascinating and I decided to pursue a second career working in this field.
In 2011, I began a four year PhD entitled 'Managing genomic diversity in the course of selection' at the Roslin Institute which is part of the University of Edinburgh. More info on my postgraduate work can be found here or by clicking the link on the postgraduate link towards the top of the page.
I am currently working as a post-doctoral research fellow examining the genetics of depression in humans. This is a three year position within a project known as Stratifying Resilience and Depression Longitudinally (STRADL) which is funded by the Wellcome Trust. You can see my boss talking about the project here: https://www.youtube.com/watch?v=P1LrHmXHYLw.
Below are links to published papers of my research and also papers that I have contributed to:
Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways
Howard, D. M., Adams, M. J., Shirali M. et al. biorXiv, (2017). preprint
The stratification of major depressive disorder into genetic subgroups
Howard, D. M., Clarke, T-K., Adams, M. J. et al. biorXiv, (2017). preprint
Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank
Howard, D. M., Adams, M. J., Clarke, T-K. et al. Wellcome Open Res, (2017). 2:61
Use of haplotypes to identify regions harbouring lethal recessive variants in pigs
Howard, D. M., Pong-Wong, R., Knap, P. W. & Woolliams, J. A. Genetics Selection Evolution, (2017). 49:57
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117)
Clarke, T-K., et al. Molecular Psychiatry, (2017) 22, 1376-1384
Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)
Wigmore, E., et al. Translational Psychiatry, (2017) 7:e1205
Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data.
Gibson, J., et al. Translational Psychiatry, (2017) 7:e1094
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants
Nagy, R., et al. Genome Medicine, (2017). 9:23
Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism
Clarke, T-K., et al. biorXiv, (2017). preprint
Accelerated Epigenetic Ageing in Major Depressive Disorder
Whalley, H. C., et al. biorXiv, (2017). preprint
116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals
Luciano, M., et al. biorXiv, (2017). preprint
Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)
Shen, X., et al. biorXiv, (2017). preprint
Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank
Hall, L. S., et al. biorXiv, (2017). preprint
Genome-wide regional heritability mapping identifies a locus within the TOX2 gene associated with Major Depressive Disorder
Zeng, Y., et al. Biological Psychiatry, (2016). 82(5):312-321